Short communication ACTH4-10 ANTAGONISM OF MORPHINE-INDUCED BEHAVIORAL ACTIVATION IN THE MOUSE
نویسنده
چکیده
R.J. KATZ, A CTH~_l o antagonism of morphine-induced behavioral activation in the mouse, European J. Pharmacol. 53 (1979) 383--385. The 4-10 fragment of adrenocort icotrophic hormone (ACTH4_10; Met-Glu-His-Phe-Arg-Trp-Gly) was administered intracerebroventricularly to C57B1 mice with and without concurrent systemic injection of a standard dose of morphine sulfate. Morphine produced s tereotyped behavioral activation (running, environmental oblivion, Straub tail) which was ai l tagonized in a dose related fashion by the ACTH fragment. This extends the range of opiate--ACTHa_l n interactions to a novel species and behavioral model, and is consistent with previous findings.
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